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Monday, November 9, 2009
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Medication

In most people with hypertrophic cardiomyopathy, medications successfully relieve the symptoms and let patients maintain a relatively active lifestyle. The drugs that are most effective in treating HCM either slow down the heart rate or reduce the strength of the contractions of the heart muscle. This lets the heart fill more completely with blood between contractions, which minimizes the risk of obstruction and keeps the heart working efficiently. Relaxing the heart muscle, not stimulating it, helps the heart pump more efficiently for people with HCM.

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Common Medications Used For Treatment of Patients with Hypertrophic Cardiomyopathy

Class Mechanism Side Effects
Beta-Blocker Slow heart rate, Decrease contraction Heart rate too slow, Blood pressure too low, Fatigue, Nightmares, Impotence
Calcium Channel Blocker Slow heart rate, Decrease contraction, Relax heart muscle Heart rate too slow, Blood pressure too low, Swelling, Constipation, Fatigue
Gp I Antiarrythmic Decrease contraction, Prevent abnormal rhythms Dry mouth, Urinary retention
Gp III Antiarrythmic Slow heart rate, Prevent abnormal rhythms Skin pigmentation changes (stay out of sun), Lung abnormalities, Thyroid abnormalities

Beta-blockers are generally the most effective drug, and the best tolerated by most patients with HCM, but may require relatively high dosages to be effective. The treatment goal of relieving symptoms may require keeping the resting heart rate at less than 60 beats per minute without compromising the blood pressure levels. However, some people may not tolerate the side effects associated with beta-blockers such as nightmares, impotence, and fatigue.

Calcium channel blockers are a good alternative for individuals who cannot tolerate beta-blockers. Calcium-channel blockers must be prescribed with caution because there have been several reported instances of sudden death after the first dose in patients with very severe obstruction.

Antiarrythmic medication is an alternative for patients who are intolerant of beta-blockers and calcium channel blockers. Although these drugs have been successful in some cases, the side effects of urine retention and dry mouth preclude their use in many patients. The patients who best tolerate antiarrythmics appear to be young women.

Although drug therapy works well for most people, not everyone responds to medications. Others may become intolerant of the drug or develop severe symptoms of HCM after a few years on medications. In these patients, alternative treatments must be considered.

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