The fibrates, fenofibrate (Lofibra, Tricor) and gemfibrozil (Lopid), are the treatment of choice for those with markedly increased blood triglyceride levels. But any reduction in triglycerides with fibrates may be accompanied by a slight rise in LDL cholesterol. When this problem occurs, the addition of a statin can improve LDL cholesterol levels but may cause muscle inflammation in about 1 percent of people. (The problem is more common with gemfibrozil than with fenofibrate.) Muscle inflammation is reversible, but both drugs must be promptly discontinued, since persistent, severe muscle inflammation can cause kidney failure.
For more on side effects, see
Lipid-Lowering Drugs (PDF).
