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A surgical procedure called macular translocation may be an option when the growth of abnormal blood vessels and fluid leakage are happening directly under the center of the macula, where a laser beam cannot safely be directed. The surgeon partly detaches the retina, leaving intact connections to the optic nerve, and rotates it very slightly so the macula is moved over healthy tissue. A bubble of air is injected into the eye to hold the retina in place while it heals. The light-sensing rods and cones of the macula may function better in the healthier position, and laser therapy can be used to destroy the previously covered blood vessels.

Research is also being done on additional anti-VEGF drugs and on anecortave acetate (Retaane), which also blocks the growth of new blood vessels but is injected behind the eye rather than into the eyeball.