Preventive medication for migraines

If your headaches are frequent, long in duration, or particularly disabling, a preventive medication may be warranted. Preventive medications reduce the frequency and severity of the headaches and are generally taken on a regular, daily basis.

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Some commonly prescribed preventive medications include:

• Nonsteroidal anti-inflammatory drugs (NSAIDs) when taken pre-emptively
• Antidepressant medications such as amitriptyline (Elavil)
• Antihistamines, such as cyproheptadine (Periactin)
• Beta blockers such as propranolol (Inderal)
• Calcium channel blockers such as verapamil (Calan and Isoptin)
• Anticonvulsant medication such as divalproex (Depakote) and topiramate (Topamax)

Up to 70 percent of migraines can be modified with the use of preventive medications. Often, however, a combination of symptomatic and preventive medications may be necessary.

Since these medications may cause side effects, it's important to consult your doctor about your risks.