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Calcium channel blockers
Calcium channel blockers, used in the treatment of several heart-related disorders, have not been approved by the Food and Drug Administration for treatment of headaches. However, they have been studied for vascular headaches and have been shown to be effective in preventing migraine as well as cluster headaches. They are widely used for headache treatment and work by unknown mechanisms. Some calcium channel blockers prescribed for headaches are verapamil (Calan, Covera, Isoptin, Verelan), nimodopine (Nimotop), and diltiazem (Cardizem, Dilacor).
A calcium channel blocker may take two to four weeks to be effective. Be sure to continue taking it as instructed by your doctor, even after symptoms disappear. Do not stop taking a calcium channel blocker without first talking to your doctor, as you could make your condition worse. Avoid grapefruit and grapefruit juice, which may interfere with absorption.
Side effects may include nausea, dizziness, constipation, difficulty urinating, and fatigue. Call your doctor immediately if any of your side effects change in intensity or if you experience any other symptoms that you think could be caused by this medicine.
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