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St.-John's-wort and adverse reactions
Many so-called natural substances can have harmful effects--especially if they are taken in too large a quantity or they interact with something else the person is taking.
St.-John's-wort interacts with a variety of drugs, including certain drugs used to control HIV infection (such as indinavir) and chemotherapeutic, or anticancer, drugs (such as irinotecan). The herb may also interact with drugs that help prevent the body from rejecting transplanted organs (such as cyclosporine). Using St.-John's-wort limits these drugs' effectiveness.
People taking St.-John's-wort can experience adverse reactions. They include a dry mouth, dizziness, diarrhea, nausea, increased sensitivity to sunlight, and fatigue.
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