Cancer's fearsome travelers
It's a not-so-fantastic voyage. A single cell somehow breaks off from a tumor and makes its way into the bloodstream, traveling through dark arteries and capillaries until it finds a resting spot in some far reach of the body. Once situated, it might immediately invade the surrounding tissue, replicating itself in a frenzy. Or it might just lie dormant--for as long as a decade, long after the original tumor is gone--until a mysterious signal tells it to start growing.
These cellular ramblings and sojourns are technically known as metastasis, and they are what make cancer a killer. Surgeons can often remove a tumor. That's the easy part. But the invisible spawn of this tumor may have already infiltrated the body. Indeed, much basic cancer research in recent years has focused on these minuscule but deadly cells.
The focus of metastasis inquiry is shifting. As important as these "seeds" are to metastasis, equally as important is what physician Stephen Paget called the "soil"--the varied environments that tumor cells encounter as they travel. Paget's pathbreaking thesis, published in the Lancet in 1889, is that metastasis involves a complicated biochemical "conversation" between the seed and soil--cell and host--at every step along the way. Scientists are now taking a harder look at how the body itself can lure, influence, and even hide the errant cell. Though much of the research is still being done in petri dishes and small animals, researchers believe it offers hope for new targets for cancer therapies. "The time has come to put the major emphasis on the soil," says researcher Isaiah Fidler of the M. D. Anderson Cancer Center in Houston.
Traveling long distance through the body is not easy and requires some physiological cleverness. A breakaway tumor cell must invade the surrounding tissue to find either the bloodstream or lymphatic system--the most uncongested avenues of transport. One way to do this is for the cell to cultivate its own lymphatic vessels from the surrounding tissue. Indeed, research has shown that a malignant cell's ability to commandeer the body's lymph system is a good predictor both of later metastasis--and poor prognosis for survival.
Battered. The cells that actually make it to the bloodstream still face long odds. Like small boats in a storm, they have a good chance of being battered to pieces by the currents in the bloodstream. "A tumor may be releasing millions of cells per day, but we don't see patients with millions of metastases," says Joan Massague, head of Memorial Sloan-Kettering's cancer biology and genetics program. But some do survive. And research published in the Proceedings of the National Academy of Sciences in November raises the possibility that these stalwarts are helped in their odyssey by platelets, the saucerlike, clot-forming bodies in the blood. Just how is unknown, but Washington University's Katherine Weilbaecher speculates: "What we think is happening is that the cancer cells actually activate the platelets, get stuck to them, and the platelets form webs over the cancer cells." The platelets might even be nourishing the tumor cells, protecting them from detection or helping them to get a foothold in the blood vessels. This is all based on experimental animal work, but it's promising because there are many anticlotting drugs--including simple aspirin--available right now. Weilbaecher is designing a study to examine the phenomenon in humans.
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