Study of Genetic Condition May Yield Clues to Cause of Allergies

Results from kids with Loeys-Dietz syndrome might help guide treatment of all allergic diseases, researchers say

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Noting the similar immune response that researchers found in children with and without Loeys-Dietz syndrome, he said, "The problem with that is you don't know if that's related to the same type of TGF-beta receptor defects. It may just be if you're allergic, that's what you do."

If TGF-beta does end up being the culprit behind allergies, there are already-approved drugs on the market that are aimed at reducing TGF-beta signaling, study author Frischmeyer-Guerrerio said. One is the blood pressure medication losartan, which did reduce signaling in syndrome patients.

"Now, the next step will be for us to look at ways to inhibit this pathway," she said.

More information

The U.S. National Library of Medicine has more about Loeys-Dietz syndrome.

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