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Cedars and Sandin both said more studies are needed to see how children fare after IVF, and to dig for reasons for the current findings on ICSI.

Between 1978 and 2012, about 5 million children worldwide were born via IVF, and the numbers will only increase, Cedars said. And in some countries -- including the United States -- intracytoplasmic sperm injection is being increasingly used in cases in which there is no clear problem with the man's fertility, because there is a perception that it's more efficient.

But that belief, Sandin's team said, is unproven.

More information

The American Society for Reproductive Medicine has more on in vitro fertilization and intracytoplasmic sperm injection.

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