The reason for the success of this particular combination is that it quickly kills Cryptococcus, according to the author of an accompanying editorial, Dr. John Perfect, of Duke University Medical Center in Durham, N.C. "In cryptococcal meningitis, the principle is set: the rapid killing of yeasts at the site of infection translates into a better outcome," he wrote.
"Long-term success in the treatment of cryptococcal meningitis depends on how well we kill yeasts with the initial treatment regimen," Perfect added.
The study, which was funded by the Wellcome Trust and the British Infection Society, is published in the April 4 issue of the New England Journal of Medicine.
To learn more about Cryptococcus, visit the U.S. Centers for Disease Control and Prevention.
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