By Steven Reinberg and Margaret Steele
SATURDAY, Oct. 20 (HealthDay News) -- Twenty-three people have now died and 284 have been sickened in the nationwide meningitis outbreak apparently tied to contaminated steroid injections, U.S. health officials reported Saturday.
The count stood at 21 deaths and 271 infections on Friday.
Federal health officials said Thursday that fungus found in steroid injections produced by a Massachusetts specialty pharmacy matched the fungus linked to the outbreak. The officials said they'd confirmed the presence of the fungus, Exserohilum rostratum, in unopened vials of a steroid produced by the New England Compounding Center.
The vial came from one of three lots recalled by the Framingham-based company last month, officials from the U.S. Centers for Disease Control and Prevention and the U.S. Food and Drug Administration said.
The steroid, methylprednisolone acetate, is injected into patients for back and joint pain. The company has since shut down operations and stopped distributing its products, health officials said.
The CDC and state health departments estimate that roughly 14,000 patients may have gotten steroid injections from the three lots, and nearly 97 percent of them have been contacted for medical follow-up.
Meningitis is a potentially fatal inflammation of the lining surrounding the brain and spinal cord.
On Friday, the New England Journal of Medicine published two articles on the outbreak, including a report on what's believed to be the first case in the outbreak -- a man in his 50s with a history of back and joint pain. He showed up at Vanderbilt University Medical Center in Nashville complaining of head and neck pain. Despite a series of medical interventions, he died after a 22-day stay at the hospital.
An autopsy revealed the presence of the fungus Aspergillus fumigates. It's the only case of this type of fungus detected in the outbreak so far; all other cases apparently involved the fungus Exserohilum rostratum, the journal said.
In a commentary accompanying the case report, doctors said many of the patients affected by the outbreak have been older adults with preexisting health problems, making treatment decisions difficult. At this point, the best treatment seems to be at least three months of antifungal therapy, the doctors who wrote the commentary said.
All of the fungal meningitis patients identified so far were thought to be injected with methylprednisolone acetate from the Massachusetts pharmacy, according to the CDC.
Three of the cases have been what the CDC calls "peripheral joint infection," meaning an infection in a knee, hip, shoulder or elbow. These joint infections aren't considered as dangerous as injections near the spine for back pain that have been linked to the potentially fatal meningitis infections.
The 14,000 people who may have gotten injections of the steroid include not only patients who got shots for back pain and are most at risk for meningitis, but also others who received shots for pain in their knees and shoulders.
The FDA said it was advising all health care professionals to follow up with any patients who were given any injectable drug from or produced by the New England Compounding Center. These drugs include medications used in eye surgery, and a heart solution purchased from or produced by the company after May 21.
The New England Compounding Center is what's known as a compounding pharmacy. These pharmacies combine, mix or alter ingredients to create specific drugs to meet the specific needs of individual patients, according to the FDA. Such customized drugs are frequently required to fill special needs, such as a smaller dose, or the removal of an ingredient that might trigger an allergy in a patient.
The CDC on Saturday had the following state-by-state breakdown of cases: Florida: 17 cases, including 3 deaths; Idaho, 1 case; Illinois, 1 case; Indiana: 37 cases, including 2 deaths; Maryland: 16 cases, including 1 death; Michigan: 53 cases, including 5 deaths; Minnesota: 7 cases; New Hampshire: 10 cases; New Jersey: 16 cases; New York: 1 case; North Carolina: 2 cases, including 1 death; Ohio: 11 cases; Pennsylvania: 1 case; Tennessee: 69 cases, including 9 deaths; Texas: 1 case; Virginia: 41 cases, including 2 deaths.