By Serena Gordon
THURSDAY, Dec. 15 (HealthDay News) -- A long-awaited U.S. government-mandated report from the Institute of Medicine (IOM) recommends that the use of chimpanzees in biomedical research be conducted only in very limited circumstances.
The IOM, an independent body that is often charged with reviewing medical or scientific issues, has developed two sets of criteria to be used for deciding whether or not chimpanzees were necessary for biomedical research and for behavioral research.
The criteria included factors such as whether another suitable research model might be available, or whether the research could not be ethically performed in human subjects.
Based on this criteria, the panel concluded that the use of chimpanzees is not necessary for most medical research. One area where the committee felt chimpanzee research could possibly still provide a benefit in biomedical research was in monoclonal antibodies (a form of therapy used against cancer and other illnesses). The committee was spilt on whether such research might be necessary for the development of a preventive hepatitis C vaccine.
"When we applied the criteria to a number of disease areas and considered: 'Is there another model that could be used?' and 'Could this be done ethically in humans?' in many cases, the answer was yes," said committee member, Sharon Terry, president and CEO of Genetic Alliance in Washington D.C.
"The trajectory here is clear. While chimps were very useful in prior years, we will see a decline in their use in research," said Terry.
According to the Associated Press, the United States and the West African country of Gabon are the only two countries in the world known to conduct medical research with chimpanzees. The European Union banned this type of research in 2010. The use of chimpanzees for research in the United States has been on the decline, the AP said, with less than 1,000 animals now available in the country for medical research nationwide.
One group that's long lobbied for less medical research on chimpanzees was largely pleased with the IOM's findings.
"The current report is precedence-setting. It's the first time in modern science that anyone other than a human has been given this much attention, but we'll continue to work for the day when there's no research on chimpanzees," said Theodora Capaldo, president and executive director of the New England Anti-Vivisection Society and Project R&R: Release and Restitution for Chimpanzees in U.S. Laboratories.
The IOM's report, called Chimpanzees in Biomedical and Behavioral Research: Assessing the Necessity, was released on Dec. 15. The report was commissioned by the U.S. National Institutes of Health (NIH). The NIH provides funding for the care of many of the chimpanzees that are currently used in medical research.
In biomedical research, the IOM's criteria for continued use of chimpanzees in research include:
- There is no other suitable model available, such as in vitro, non-human in-vivo, or other models for the research in question.
- The research in question cannot be performed ethically on human subjects.
- Forgoing the use of chimpanzees for the research in question will significantly slow or prevent important advancements to prevent, control and/or treat life-threatening or debilitating conditions.
Similar criteria were developed for comparative genomic and behavioral research. These criteria also included guidelines that techniques used in research on chimpanzees must be minimally invasive, with care taken to minimize any pain and distress.
In addition, the IOM report says that chimpanzees in either type of research must be maintained in "ethologically appropriate physical and social environments or in natural habitats." However, they added that current research is exempt from these criteria.
One area that met the criteria was monoclonal antibody research. Monoclonal antibodies have been used in the treatment of inflammation, autoimmunity, cardiovascular disease, cancer, macular degeneration, and transplantation, according to the report. New technology is being developed that would make chimpanzee research unnecessary in this field, but to avoid stalling current research and delaying access to potentially life-saving medications, the IOM committee felt that this research met their criteria.