Know when to take it inside. There is a point when layers and acclimation only go so far – when uncomfortable weather becomes unsafe. Check the weather conditions before your run. If the wind chill is extreme or the temperature is well below zero, Mayo Clinic suggests skipping your workout or taking it inside. Even if you're not interested in the gym, there are plenty of exercises you can do anywhere, including indoors. Honerkamp also suggests runners be conscious of footing conditions, like ice.
"I'll run in 10 degrees," he says, "but I usually go to the treadmill when it's icy."