Health Tip: Options to Help Insomnia

Silenor (doxepin) is a sleep-specific, low-dose (3mg and 6mg), per oral tablet formulation of doxepin for use in insomnia. In contrast to higher-dose doxepin, Silenor is a potent antagonist that appears to selectively affect histamine at the H1 receptor without a clinically relevant impact on other neurotransmitter systems. Histamine is an important waking neurotransmitter, and the blockade of histamine is believed to play an important role in the promotion of sleep. Doxepin is approved in the Europe for the treatment of depression and anxiety at doses of 75mg-300mg daily. Doxepin at higher doses has been associated with a range of pharmacologic side effects that include anticholenerigic effects (dry mouth, constipation, etc.) and weight gain. In clinical trials, patients taking Silenor generally did not exhibit the side effects associated with higher doses of doxepin.

health regulators declined to approve its insomnia drug Silenor in Unite State, but in three month will be new validation evaluation and reconsidering FDA its position with in 6 month approval.

Monica of FL 2:35PM December 09, 2009