Ginkgo Prevented Stroke Damage in Mice

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By Ed Edelson
HealthDay Reporter

THURSDAY, Oct. 9 (HealthDay News) -- A study with genetically engineered mice found that an extract from the leaves of the ginkgo tree can prevent or reduce brain damage from a stroke.

The ginkgo extract appears to help by neutralizing the activity of free radicals, molecules known to attack and kill cells, explained study author Sylvain Dore, an associate professor of anesthesiology and critical care medicine at Johns Hopkins University, in Baltimore.

"What is interesting here is that we are looking at a mechanism of action that has not been proposed before," Dore added.

The Hopkins group is already getting ready to design human trials of ginkgo treatment for stroke, Dore said. "We want to see what is the optimal therapeutic window, the safest dose, how long after a stroke it can be given," he said.

The findings appear in the Oct. 10 issue of Stroke.

The report drew a quick, skeptical response from Dr. Larry B. Goldstein, director of the Duke University Stroke Center.

"This is basically an animal model study trying to look at the central mechanism of action of ginkgo as a neuroprotective drug," Goldstein said. "We've been down this pathway a hundred times already, and none of these animal models have proven to be effective in generating FDA-worthy evidence."

In the study, Dore and his colleagues worked with both normal mice and mice bred to lack the enzyme heme oxygenase. Some mice were given standardized doses of the gingko extract for seven days while others weren't. Brain arteries in the rodents were then blocked to cause a stroke.

Tests showed that normal mice that got the ginkgo extract had 50.9 percent less neurological damage and 48.2 percent smaller areas of brain damage than mice that didn't get the extract.

"What we have shown here is that by induction of an antioxidant enzyme, ginkgo extract can be effective," Dore said.

The results were encouraging enough that "we have put a team together to design an optimal clinical trial," he said.

Don't bother, Goldstein said. "There have been a bunch of clinical trials done in Europe," he said. "In a meta-analysis, the bottom line conclusion was that there was no clear benefit in trials that were methodologically sound."

Dore and Goldstein agreed on one point -- that the study results should not prompt people to start using the well-advertised ginkgo products that are widely available and touted as memory enhancers.

The Hopkins trial used a standardized extract, while the quality of the extracts sold commercially can be uncertain, Dore said.

"Ginkgo can interact with prescribed drugs and aspirin, and there is the risk of bleeding complications," Goldstein noted. One recent trial of ginkgo as a memory booster in older people even found a slightly increased risk of stroke, he said.

More information

The U.S. Centers for Disease Control and Prevention describes proven ways to reduce the risk of stroke.

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