Our awareness of the protective effects of Vitamin D against various manifestations of cancer seems to be growing by the day. Here's a study that suggests potential disruption of the metastatic cascade by Vitamin D in prostate cancer cells.
http://www.ncbi.nlm.nih.gov/pubmed/21281819
Title: Suppression of prostate cancer cell rolling and adhesion to endothelium by 1α,25-dihydroxyvitamin D3
Authors: Hsu JW, Yasmin-Karim S, King MR, Wojciechowski JC, Mickelsen D, Blair ML, Ting HJ, Ma WL, Lee YF; Department of Urology and Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA.
Abstract: Adhesion of circulating prostate cancer (PCa) cells to the microvascular endothelium is a critical step during cancer metastasis. To study PCa cell rolling and adhesion behavior, we developed a dynamic flow-based microtube system to mimic the microvascular environment. We found that PCa cell rolling capacity is mediated by E-selectin and can be enhanced by stromal cell-derived factor-1 under different wall shear stresses. Using this device, we tested if the chemopreventive agent, vitamin D, could interfere with PCa cell adhesion. We found that 1α,25-dihydroxyvitamin D(3) (1,25-VD), the bioactive form of vitamin D, reduced PCa cell rolling numbers and increased rolling velocities resulting in a significant decreased number of PCa cells adhering to the microtube. The inhibitory effects of 1,25-VD on PCa cell heterotypic adhesion were further confirmed using microvascular endothelial cells in a static condition. Furthermore, we demonstrated that 1,25-VD can increase E-cadherin expression in PCa cells and promote the homotypic cell-cell aggregation, which can then hinder PCa cell adhesion to the endothelium. Blocking E-cadherin with a neutralizing antibody can reverse 1,25-VD-mediated suppression of PCa cell adhesion to the endothelium. Taken together, our data revealed that 1,25-VD promoted PCa cell aggregation by increasing E-cadherin expression, thus interfering with circulating PCa cell adhesion to microvascular endothelial cells and potentially reducing their metastatic potential.
Melioraof NY10:47AM June 13, 2011
Low level of vitamin d causes many other health problem like osteomalacia in adults, rickets in children, cognitive decline, hypertension, diabetes etc
This deficiency can be cured by taking foods like cheese, butter, fish, cod liver oil, eggs, mushrooms ,etc or by taking supplements ,but care should be taken while consuming these supplements because overdose of it might lead to ailments like calcification, urinary stones, muscle weakness, etc.
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Meliora of NY 10:47AM June 13, 2011
Eva George 6:51AM May 17, 2011