Repair of membrane structure is energy intense. Hence the mitochondrial link is straightforward. In addition to energy, repair of membrane structure is dependent upon methyl group metabolism and the vitamins choline, B6, B12, folic acid. All these vitamins are deficient in the American diet and progressively more so with age. The hippocampus is more dependent on methyl group metabolism than other areas of the brain because the leading memory neurotransmitter is acetyl choline.
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Keith Beatty of CA 10:19PM February 28, 2011