"People study lots of things and look for associations," he noted. "And while it's not too far a stretch to say that wrinkles might be associated with bone loss, there are so many variables at play -- like sun exposure and nutrition and so many other things -- that it would be hard for me to say that this [skin] could be a valuable screening tool, unless the sensitivity and specificity of this specific relationship was high enough."
"You don't want to give people a false sense of security that wrinkles are always an indication of bone loss, or that if you don't have wrinkles you don't have bone loss, unless there is clearly a very high connection between the two," Rosenwasser added. And to determine that, a much larger study is needed, he said.
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