Analgesics such as NSAIDs have been shown to provide relief for the physical symptoms of PMS such as headaches, cramps, and pain when taken several days prior to and during the first days of menstruation. Patients should only take the recommended dose and be advised of possible adverse effects.
Magnesium deficiency may lead to symptoms of irritability associated with PMS. Results from one clinical study demonstrated that a daily dose of 360 milligrams of magnesium taken during the luteal phase may provide some relief from PMS symptoms. Patients can be advised to take 360 mg. of magnesium daily during the premenstrual phase only. Magnesium may cause diarrhea in some patients.
Pyridoxine (Vitamin B6)
Vitamin B6 has been used to treat PMS symptoms such as irritability, fatigue, bloating, and depression. Studies have shown that a dose of 80 mg. per day can improve mood and anxiety levels. Recommended doses should be limited to 100 mg. daily to reduce the incidence of neuropathy.
Calcium and Vitamin D
Results from one study showed that high dietary intake of calcium and vitamin D may prevent the development of PMS symptoms. Patients should take 1,200 mg. daily in divided doses, with no more than 500 mg. per dose. Because calcium may cause gastric upset or constipation, it should be taken with food. Patients should be advised to also take at least 600 IU of vitamin D per day.
Note: This article was originally published on June 12, 2012 on PharmacyTimes.com. It has been edited and republished by U.S. News.